膵α細胞におけるインスリンシグナル分子の役割に関する論文がJ Biol Chem.に発表されました
#Takatani T, #Shirakawa J, #Shibue K, Gupta MK, Kim H, Lu S, Hu J, White MF, Kennedy RT, Kulkarni RN. Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. J Biol Chem. 296:100646, 2021 (#共筆頭著者:白川純)
2型糖尿病における血漿中xanthine oxidoreductase activityの意義に関する論文がSci Repに発表されました
Okuyama T, *Shirakawa J, Nakamura T, Murase T, Miyashita D, Inoue R, Kyohara M, Togashi Y, Terauchi Y. Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes. Sci Rep. 11(1):3768, 2021. (*責任著者:白川純)
新規遺伝性糖尿病原因遺伝子ZYG11Aの膵β細胞での機能に関するMahidol Universityとの共同研究がMol Cell Endocrinolに発表されました
Charoensuk C, Thamtarana PJ, Chanprasert C, Tangjittipokin W, Shirakawa J, Togashi Y, Orime K, Songprakhon P, Chaichana C, Abubakar Z, Ouying P, Sujjitjoon J, Doria A, Plengvidhya N, Yenchitsomanus PT. Autosomal Dominant Diabetes Associated with a Novel ZYG11A Mutation Resulting in Cell Cycle Arrest in Beta-Cells. Mol Cell Endocrinol. 522:111126, 2021.
Harvard Medical School, Joslin Diabetes Centerとの共著論文がStem Cell Reportsに発表されました
Gupta MK, Vethe H, Softic S, Rao TN, Wagh V, Shirakawa J, Barsnes H, Vaudel M, Takatani T, Kahraman S, Sakaguchi M, Martinez R, Hu J, Bjørlykke Y, Raeder H, *Kulkarni RN. Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells. Stem Cell Reports. 15(5):1067-1079, 2020.
組織特異的なインスリン抵抗性を反映するバイオマーカーの論文がDiabetol Metab Syndrに発表されました
Kyohara M, *Shirakawa J, Okuyama T, Togashi Y, Inoue R, Li J, Miyashita D, Terauchi Y. Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects. Diabetol Metab Syndr. 12:83, 2020.(*責任著者:白川純)
